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We for the very first time report selective inhibitors could be intended towards TR by combining the hydrophobic interaction of inhibitors with conserved Leu399 substitution and surrounding amino acids with charge-based interaction of Glu466 and G read more...

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Wherever Leu399 is a conservative substitution from GR among TR of all the Trypanosomatids, this further hydrophobic area existing in the vicinity of the substrate-binding read more...